Faruqi & Faruqi, LLP Securities Litigation Partner James (Josh) Wilson Encourages Investors Who Suffered Losses Exceeding $50,000 In Applied Therapeutics To Contact Him Directly To Discuss Their Options If you suffered losses exceeding $50,000 in Applied Therapeutics January 3, 2024 and December 2, 2024 and would like to discuss your legal rights, call Faruqi & Faruqi partner Josh Wilson directly at 877-247-4292 or 212-983-9330 (Ext. 1310) . [You may also click here for additional information] NEW YORK, Dec. 26, 2024 (GLOBE NEWSWIRE) -- Faruqi & Faruqi, LLP , a leading national securities law firm, is investigating potential claims against Applied Therapeutics, Inc. ("Applied Therapeutics" or the "Company") APLT and reminds investors of the February 18, 2025 deadline to seek the role of lead plaintiff in a federal securities class action that has been filed against the Company. Faruqi & Faruqi is a leading national securities law firm with offices in New York, Pennsylvania, California and Georgia. The firm has recovered hundreds of millions of dollars for investors since its founding in 1995. See www.faruqilaw.com . As detailed below, the complaint alleges that the Company and its executives violated federal securities laws by making false and/or misleading statements and/or failing to disclose that defendants provided positive statements to investors while, at the same time, disseminating false and materially misleading statements and/or concealing material adverse facts concerning the true state of Applied Therapeutics' Phase III INSPIRE trial; notably, electronic data capture issues and a dosing error in the dose-escalation phase of the study. Such statements absent these material facts caused Plaintiff and other shareholders to purchase Applied Therapeutics' securities at artificially inflated prices. On November 27, 2024, Applied Therapeutics issued a press release announcing "that the U.S. Food and Drug Administration (FDA) has issued a Complete Response Letter (CRL) for the New Drug Application (NDA) for govorestat, a novel, central nervous system (CNS)-penetrant aldose reductase inhibitor (ARI), for the treatment of Classic Galactosemia." According to the Company, "[t]he CRL indicates that the FDA completed its review of the application and determined that it is unable to approve the NDA in its current form, citing deficiencies in the clinical application." On this news, Applied Therapeutics' stock price fell $1.64 per share, or 16.06%, to close at $8.57 per share on November 27, 2024. Then, on December 3, 2024, the FDA posted on its website a Warning Letter to Applied Therapeutics, the contents of which indicated that the Company was aware at least as early as May 2024 that the FDA had identified significant issues in the govorestat NDA. On this news, Applied Therapeutics' stock price fell $0.31 per share, or 18.34%, to close at $1.38 per share on December 4, 2024. The court-appointed lead plaintiff is the investor with the largest financial interest in the relief sought by the class who is adequate and typical of class members who directs and oversees the litigation on behalf of the putative class. Any member of the putative class may move the Court to serve as lead plaintiff through counsel of their choice, or may choose to do nothing and remain an absent class member. Your ability to share in any recovery is not affected by the decision to serve as a lead plaintiff or not. Faruqi & Faruqi, LLP also encourages anyone with information regarding Applied Therapeutics' conduct to contact the firm, including whistleblowers, former employees, shareholders and others. To learn more about the Applied Therapeutics class action, go to www.faruqilaw.com/APLT or call Faruqi & Faruqi partner Josh Wilson directly at 877-247-4292 or 212-983-9330 (Ext. 1310) . Follow us for updates on LinkedIn , on X , or on Facebook . Attorney Advertising. The law firm responsible for this advertisement is Faruqi & Faruqi, LLP ( www.faruqilaw.com ). Prior results do not guarantee or predict a similar outcome with respect to any future matter. We welcome the opportunity to discuss your particular case. All communications will be treated in a confidential manner. A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/1b78d6d9-524e-4bfa-9772-9599dc664268 . © 2024 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.Israel strikes Houthi rebels in Yemen's capital while WHO chief says he was meters awayjilibay app download ios 。

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CLEVELAND (AP) — Shortly after doing a face-down snow angel, firing a few celebratory snowballs and singing “Jingle Bells” on his way to the media room, Jameis Winston ended his postgame news conference with a simple question. “Am I a Brown yet?” he asked. He is now. And who knows? Maybe for a lot longer than expected. Winston entered Cleveland football folklore on Thursday night by leading the Browns to a 24-19 win over the division rival Pittsburgh Steelers, who had their five-game winning streak stopped. Winston's performance at Huntington Bank Field, which transformed into the world's largest snow globe, not only made him an instantaneous hero in the eyes of Browns fans but added another wrinkle to the team's ever-changing, never-ending quarterback conundrum. In his fourth start since Deshaun Watson's season-ending Achilles tendon injury, Winston made enough big plays to help the Browns (3-8) get a victory that should quiet conjecture about coach Kevin Stefanski's job. Some wins mean more than others. In Cleveland, beating the Steelers is as big as it gets. But beyond any instant gratification, Winston has given the Browns more to consider as they move forward. Watson's future with Cleveland is highly uncertain since it will still be months before the team has a grip on whether he's even an option in 2025, his fourth year since signing a $230 million, fully guaranteed contract that has proven calamitous. It's also possible the Browns will cut ties with Watson. They signed Winston to a one-year contract to be Watson's backup. But the unexpected events of 2024 have changed plans and led to the possibility that the 30-year-old Winston could become Cleveland's full-time QB or a bridge to their next young one. So much is unclear. What's not is that Winston, who leaped into the end zone on fourth-and-2 for a TD to put the Browns ahead 18-6 in the fourth quarter, is a difference maker. With his larger-than-life personality and the joy he shows whether practicing or throwing three touchdown passes, he has lifted the Browns. A man of faith, he's made his teammates believe. Winston has done what Watson couldn't: made the Browns better. “A very, very authentic person,” Stefanski said Friday on a Zoom call. “He’s the same guy every single day. He's the same guy at 5 a.m. as he at 5 p.m. He brings great energy to everything he does, and I think his teammates appreciate that about him.” Winston, who is 2-2 as a starter with wins over the Steelers and Baltimore Ravens, has a knack for inspiring through fiery, preacher-like pregame speeches. But what has impressed the Browns is his ability to stay calm in the storm. “He doesn’t get rattled,” said Myles Garrett, who had three sacks against the Steelers . “He’s just tuned in and focused as anyone I’ve seen at that position. Turn the page. There was a turnover, came back to the sideline, ‘Love you. I’m sorry. We’re going to get it back.’ He was already on to the next one, ‘How can we complete the mission?’ “I have a lot of respect for him. First was from afar and now seeing it on the field in front of me, it’s a blessing to have someone who plays a game with such a passion and want-to. You can’t ask for a better teammate when they take those things to heart and they want to play for you like we’re actually brothers and that’s what we have to attain. That brotherhood.” What's working Winston has done something else Watson couldn't: move the offense. The Browns scored more than 20 points for just the second time this season, and like Joe Flacco a year ago, Winston has shown that Stefanski's system works with a quarterback patient enough to let plays develop and unafraid to take shots downfield. What needs help The conditions certainly were a factor, but the Browns were a miserable 1 of 10 on third down, a season-long trend. However, Cleveland converted all four fourth-down tries, including a fourth-and-3 pass from Winston to Jerry Jeudy with 2:36 left that helped set up Nick Chubb's go-ahead TD run. Stock up RT Jack Conklin. Garrett outplayed Steelers star T.J. Watt in their rivalry within the rivalry partly because Conklin did a nice job containing Pittsburgh's edge rusher, who was held without a sack and had one tackle for loss. Conklin has made a remarkable comeback since undergoing reconstructive knee surgery last year. Stock down Owners Dee and Jimmy Haslam. Their desire to build a dome is well intended, but an indoor game could never come close to matching the surreal setting of Thursday night, when snow swirled throughout the stadium and covered nearly all the yard lines and hash marks. “It was beautiful,” Winston said. Injuries WR Cedric Tillman is in the concussion protocol. He had two catches before taking a big hit on the final play of the third quarter. Key numbers 9 — Consecutive home wins for the Browns in Thursday night games. Three of those have come against Pittsburgh. What's next An extended break before visiting the Denver Broncos on Dec. 2. ___ AP NFL: https://apnews.com/hub/NFL Tom Withers, The Associated Press